http://popups.lib.uliege.be/1373-5411/index.php?id=4255 Index terms fr 0 http://popups.lib.uliege.be/1373-5411/index.php?id=3725 Transmissible prion based spongiform encephalopathies propagate by conformational change of the prion's protein, PrP structure. An experimental design, relying on the utility of a new fundamental teleological action principle inherent in the topological geometry of a covariant polarized Dirac vacuum putatively driving self-organization in all autopoietic complex living systems, is developed to elucidate the fundamental nature of this conformational change. Further, PrP propagation is considered a mechanical action that can be described by 'interactive computational modes' of 'topological switching' driven by incursive oscillations occurring in the bioenergetics of the prions physical chemistry when improperly coupled to the long-range coherence of the noetic action. The experimental apparatus, a multi-level interferometer, is designed to focus this noetic field in a manner that simulates the mechanism driving PrP conformation to pathological form. Thu, 26 Sep 2024 11:23:24 +0200 Tue, 08 Oct 2024 13:54:34 +0200 http://popups.lib.uliege.be/1373-5411/index.php?id=3725