http://popups.lib.uliege.be/1373-5411/index.php?id=2595 Publications of Auteurs Donald C. Chang fr 0 http://popups.lib.uliege.be/1373-5411/index.php?id=2810 In the wave-particle duality, a free particle can be considered as a wave packet. Is there a wave property that corresponds to the rest mass of the particle? We suggest that this problem can be approached by treating the rest mass on the same footing as energy and momentum. Here we demonstrate that, by assuming that the matter wave of a particle is an excitation of a real physical field in the vacuum, one could derive the mass-energy relation from the solution of a simplified wave equation describing a free particle. This solution suggests that the rest mass of a particle is associated with a "transverse wave number", which characterizes the radial variation of the wave function in the transverse plane. This model has several appealing features. For example, it predicts that a massless particle must travel at the constant speed of light. Tue, 03 Sep 2024 14:56:05 +0200 Thu, 10 Oct 2024 09:55:30 +0200 http://popups.lib.uliege.be/1373-5411/index.php?id=2810 http://popups.lib.uliege.be/1373-5411/index.php?id=2589 Apoptosis (programmed cell death) is a very important cellular process that plays an important role in cancer. In this review, we summarize our research in three related areas : (l) Using single living cell analysis techniques to obtain important insight about the signalling mechanisms of apoptosis in mammalian cells. (2) Development of novel molecular bio-sensors for detecting caspase activation within a single living cell based on the fluorescence resonance energy transfer (FRET) method. These sensors not only enable us to study the regulating mechanisms of enzyme activation in an in vivo condition, they also provide a powerful tool for high-throughput screening of new drugs. (3) Using such biosensors, we identified several purified compounds in TCM (traditional Chinese medicine) that could be developed into novel anti-cancer drugs. Thu, 29 Aug 2024 14:42:16 +0200 Thu, 29 Aug 2024 14:44:40 +0200 http://popups.lib.uliege.be/1373-5411/index.php?id=2589